P807 Pregnancy and maternal outcomes in a cohort of patients with Inflammatory bowel disease: Encouraging data from a multi-disciplinary clinic in a tertiary center

Abstract Background Pregnant women with inflammatory bowel diseases (IBD) are prone to adverse pregnancy outcomes. This study aimed assess outcomes and disease management for pregnant patients IBD treated at a multi-disciplinary IBD- maternal-fetal medicine (MFM) clinic. Methods retrospective cohort included consecutive having singleton gestation who attended the IBD-MFM clinic Rabin Medical Center between 2012 2019. We assessed activity flare conception through cohort. Pregnancy of interest included: neonatal obstetrical outcome mode delivery. also three integrative outcomes: favorable poor an unfavorable maternal outcome. The was compared non-IBD gave birth same shift (1:5-10 control). Multivariable logistic regression used risk assessment. Results 141 1119 were included. Mean age 32[±4] years. had higher rate nulliparity (70% [50/141] vs. 30% [340/1119], p<0.001) lower BMI (21.42 kg/m2 [19.18-23.44] 22.48 [20.31-25.59], p=0.002). All other baseline characteristics comparable. Among patients, 60% (85/141) diagnosed Crohn’s (CD), rest ulcerative colitis (UC). At conception, 88% (124/141) in clinical remission, 83% (117/141) on maintenance therapy, 30.5% (43/141) biologics. Through pregnancy, 36.2% (51/141) flared, 14% (20/141) received systemic steroids, 3% (2/141) initiated new biologic. Flares significantly more frequent among UC CD (48.2%, [27/56] 28.2%, [24/85], p=0.015). majority all composite comparable cohorts, table 1. Cesarean delivery (34.8%, [49/141] 24.1%, [270/141], p=0.021). Risk analysis revealed that diagnosis not associated either or outcome, nor see 2. Conclusion In this IBD-pregnant followed MFM clinic, encouraging A